Dexamethasone linoleate, ISF-2073
Chemical Name: 9alpha-Fluoro-11beta,17,21-trihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione-21-(octadeca-cis-9,cis-12-dienoate)
项目整合开发状态: Biological Testing
项目研究机构: ISF (Originator)
合成路线:By reaction of dexamethasone alcohol (I) with methanesulfonyl chloride giving dexamethasone mesylate (II),which is the transesterified with potassium linoleate in dimethylformamide.
📌 参考资料/链接：
参考文献标题:New unsaturated esters for tropical antiphlogistic use; Synthesis and spectroscopic properties od dexamethasone-21-linoleate
文献作者:Pifferi,G.; et al.
参考来源:Arzneim-Forsch Drug Res 1976,26(1),7
📄 详细内容
合成路线:By reaction of dexamethasone alcohol (I) with methanesulfonyl chloride giving dexamethasone mesylate (II),which is the transesterified with potassium linoleate in dimethylformamide.
参考文献标题:Dexamethasone-21-linoleate
文献作者:Casta馿r,J.; Arrigoni-Martelli,E.
参考来源:Drugs Fut 1976,1(7),316
合成路线:By reaction of dexamethasone alcohol (I) with methanesulfonyl chloride giving dexamethasone mesylate (II),which is the transesterified with potassium linoleate in dimethylformamide.
参考文献标题:21-Ester von unges鋞tigten Fetts鋟reestern des Desa- und Betamethazons
文献作者:Szporny,L.; Pifferi,G.; Pinza,M.
参考来源:BE 0764130; DE 2113163; FR 2112302; GB 1292785