MPTP
Chemical Name: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
项目整合开发状态: Preclinical
项目研究机构: Aldrich (Supplier)
合成路线:The reaction of N-methyl-4-piperidone (II) with phenyllithium (I) in benzene-ethyl ether below 10 C gives 4-hydroxy-1-methyl-4.phenypiperidine (III),which is dehydrated by treating with refuxing concentrated HCl.
📌 参考资料/链接：
参考文献标题:Certain 2,6-methano-3-benzazocines
文献作者:Block,F.B.; et al.(Novartis Corp.)
参考来源:US 3341538
📄 详细内容
合成路线:The reaction of N-methyl-4-piperidone (II) with phenyllithium (I) in benzene-ethyl ether below 10 C gives 4-hydroxy-1-methyl-4.phenypiperidine (III),which is dehydrated by treating with refuxing concentrated HCl.
参考文献标题:Nouveaux benzomorphanes et leur pr閜aration
文献作者:Frank,M.; Clarke,H.Jr.(Novartis Corp.)
参考来源:DE 1445845; DE 1795599; FR 1440638; FR 4024M; GB 1050227; US 3320265
合成路线:N-Benzyl 2-aminoethanethiol (I) is reacted with 1,1-bis(methylsulfanyl)-2-nitroethene (II) in boiling ethanol to give RGH-5981.
合成路线:The reaction of N-methyl-4-piperidone (II) with phenyllithium (I) in benzene-ethyl ether below 10 C gives 4-hydroxy-1-methyl-4.phenypiperidine (III),which is dehydrated by treating with refuxing concentrated HCl.
参考文献标题:MPTP
文献作者:Casta馿r,J.; Prous,J.
参考来源:Drugs Fut 1986,11(5),384