KCB-328

Chemical Name: N-[3-Amino-4-[2-[N-[2-(3,4-dimethoxyphenyl)ethyl]-N-methylamino]ethoxy]phenyl]methanesulfonamide hydrochloride
项目整合开发状态: Preclinical
项目研究机构: Chugai (Originator), Choongwae (Not Determined), Chung Wue (Licensee)
合成路线:Alkylation of phenol (I) with 1,2-dibromoethane (II) in the presence of K2CO3 in DMF yielded bromoethyl ether (III),which was further,condensed with amine (IV) to afford tertiary amine (V).The nitro group of (V) was then reduced by either catalytic hydrogenation in the presence of Pd/C or by treatment with SnCl2 in aqueous HCl,and the resulting aniline (VI) was condensed with methanesulfonyl chloride in pyridine to give sulfonamide (VII).Finally,acid hydrolysis of the acetamido group provided the title compound.