Benextramine
Chemical Name: N,N'-Dithiobis(ethyleneimino)bis(hexane-1,6-diyl)bis(2-methoxybenzylamine)
项目整合开发状态: Biological Testing
项目研究机构:
合成路线:N-(6-Aminohexyl)cysteamine (I),synthesized according to Wineman et al.,is converted to the disulfide (II) by potassium ferricyanide oxidation.The substituent on the terminal nitrogens is introduced by condensation with the aromatic aldehyde (III) and subsequent reduction with NaBH4 of the intermediate Schiff base (IV).
📌 参考资料/链接：
参考文献标题:Molecular properties of the adrenergic alpha receptor.2.Optimum covalent inhibition by two different prototypes of polyamine disulfides
文献作者:Melchiorre,C.; Yong,M.S.; Benfey,B.G.; Belleau,B.
参考来源:J Med Chem 1978,21(11),1126-32
📄 详细内容
合成路线:N-(6-Aminohexyl)cysteamine (I),synthesized according to Wineman et al.,is converted to the disulfide (II) by potassium ferricyanide oxidation.The substituent on the terminal nitrogens is introduced by condensation with the aromatic aldehyde (III) and subsequent reduction with NaBH4 of the intermediate Schiff base (IV).
参考文献标题:Thiolethylation of amines with ethylene disulfide
文献作者:James,J.C.; Wineman,R.J.; Pomponi,A.M.; Gollis,M.H.
参考来源:J Org Chem 1962,274222-26
合成路线:N-(6-Aminohexyl)cysteamine (I),synthesized according to Wineman et al.,is converted to the disulfide (II) by potassium ferricyanide oxidation.The substituent on the terminal nitrogens is introduced by condensation with the aromatic aldehyde (III) and subsequent reduction with NaBH4 of the intermediate Schiff base (IV).
参考文献标题:Benextramine
文献作者:Benfey,B.G.
参考来源:Drugs Fut 1981,6(12),751