Methylsulfinylwarfarin

Chemical Name: 4-Hydroxy-3-[1-(4-methylsulfinylphenyl)-3-oxobutyl]-2H-1-benzopyran-2-one
项目整合开发状态: Preclinical
项目研究机构: Freie Universit鋞 Berlin (Originator)
合成路线:Reaction of 4-methylthiobenzaldehyde (I) with acetone (A) affords in a 90% yield E-4-methylmercaptophenyl-3-buten-2-one (II),which is oxidized by sodium periodate to the sulfoxide (III) in a 55% yield without forming any sulfone as byproduct.The sulfoxide then reacts with 4-hydroxycumarin without solvent at 140 C to form methylsulfinylwarifarin.The compound is purified by extraction from ether with a 1% sodium hydroxide solution and then precipitated with 10% hydrochloric acid.The yield of the last step is 30% of theory.