Wy-41770
Chemical Name: (5H-Dibenzo[a,d]cyclohepten-5-ylidene)acetic acid; 5H-Dibenzo[a,d]cycloheptene-DELTA(5,alpha)acetic acid; Dibenzo[a,d]cycloheptatrienylideneacetic acid
项目整合开发状态: Biological Testing
项目研究机构: Wyeth Pharmaceuticals (Originator)
合成路线:The Wittig condensation of triethyl phosphonoacetate (II) with 5H-dibenzo[a,d]cyclohepten-5-one (I) by means of NaH in DMSO gives the ethyl (III),which is finally hydrolyzed with KOH in refluxing ethanol.
📌 参考资料/链接：
参考文献标题:Method for treating inflammation
文献作者:Wolf,M.(American Home Products Corp.)
参考来源:EP 0035903; GB 2071098; JP 82500244; US 4267192
📄 详细内容
合成路线:The Wittig condensation of triethyl phosphonoacetate (II) with 5H-dibenzo[a,d]cyclohepten-5-one (I) by means of NaH in DMSO gives the ethyl (III),which is finally hydrolyzed with KOH in refluxing ethanol.
参考文献标题:WY-41770
文献作者:Serradell,M.N.; Casta馿r,J.; Arrigoni-Martelli,E.
参考来源:Drugs Fut 1985,10(4),309
合成路线:The Wittig condensation of triethyl phosphonoacetate (II) with 5H-dibenzo[a,d]cyclohepten-5-one (I) by means of NaH in DMSO gives the ethyl (III),which is finally hydrolyzed with KOH in refluxing ethanol.
参考文献标题:Fulvenes and thermochromic ethylenes.57.Wittig-Homer reaction with fulvene ketones and related ketones
文献作者:Bergmann,E.D.; Solomonovici,A.
参考来源:Synthesis 1970,2(4),183-189