Cefminox sodium, MT-141, Alteporina, Tencef, Meicelin
Chemical Name: 7beta-[2-[2(S)-Amino-2-carboxyethylthio]acetamido]-7alpha-methoxy-3-(1-methyl-1H-tetrazol-5-ylthiomethyl)-3-cephem-4-carboxylic acid sodium salt
项目整合开发状态: Launched-1987
项目研究机构: Bristol-Myers Squibb (Originator), Meiji Seika (Originator), Alter (Licensee)
合成路线:The reaction of 7-beta-bromoacetamido-7-alphamethoxycephalosporanic acid (I) with D-cysteine (II) in water at pH 7 gives 7-(2-aminocarboxyethylthio)acetamido-7-alpha-methoxycephalosporanic acid (III),which is then condensed with 5-mercapto-1-methyl-1H-tetrazole (IV) in water at pH 6.5-7 and at 60 C.
📌 参考资料/链接：
参考文献标题:7alpha-Methoxycephalosporin derivatives
文献作者:Iwamatsu,K.; Inoue,S.; Miyauchi,K.; Kondo,S.; Seki,S.; Yamada,Y.(Meiji Seika Kaisha,Ltd.)
参考来源:JP 55083791
📄 详细内容
合成路线:The reaction of 7-beta-bromoacetamido-7-alphamethoxycephalosporanic acid (I) with D-cysteine (II) in water at pH 7 gives 7-(2-aminocarboxyethylthio)acetamido-7-alpha-methoxycephalosporanic acid (III),which is then condensed with 5-mercapto-1-methyl-1H-tetrazole (IV) in water at pH 6.5-7 and at 60 C.
参考文献标题:MT-141
文献作者:Blancafort,P.; Casta馿r,J.; Loren,J.G.; Serradell,M.N.
参考来源:Drugs Fut 1982,7(6),395
合成路线:A new method for the synthesis of MT-141 has been reported:By condensation of 7-bromoacetamido-7alpha-methoxy-3-(1-methyl-1H-tetrazol-5-yl)thiomethyl-3-cephem-4-carboxylic acid (I) with D-cysteine (II) in aqueous NaHCO3.
参考文献标题:Synthesis and biological activity of 7beta-(2-amino-2-carboxy)-ethylthioacetamido-7alpha-methoxycephalosporin derivatives
文献作者:Iwamatsu,K.; Inouye,S.; Tsuruoka,T.; Mizutani,K.; Omoto,S.; Ogino,H.; Miyauchi,K.; Watanabe,T.; Niida,T.
参考来源:J Antibiot 1983,36(3),229-241