FKK
Chemical Name: 2,3-Dihydro-7-methyl-9-phenyl-1H-pyrazolo[1,2-a]indazolium bromide monohydrate
项目整合开发状态: Biological Testing
项目研究机构: Chugai (Originator)
合成路线:By cyclization of 5-methyl-3-phenylindazole (I) with 1,3-dibromopropane (II) by means of NaH in DMF or triethylbenzylammonium chloride NaOH in toluene - water.
📌 参考资料/链接：
参考文献标题:FKK
文献作者:Serradell,M.N.; Casta馿r,J.; Chu,S.S.
参考来源:Drugs Fut 1984,9(4),264
📄 详细内容
合成路线:By cyclization of 5-methyl-3-phenylindazole (I) with 1,3-dibromopropane (II) by means of NaH in DMF or triethylbenzylammonium chloride NaOH in toluene - water.
参考文献标题:Pharmacologic potency and selectivity of a new bronchodilator agent,2,3-dihydro-7-methyl-9-phenyl-1H-pyrazolo[1,2-a]indazolium bromide (FKK) on canine tracheal preparations 'in vivo' and 'in vitro'
文献作者:Shiraki,Y.; Sakai,K.
参考来源:Arch Intl Pharmacodyn Ther 1983,262(1),150-163
合成路线:By cyclization of 5-methyl-3-phenylindazole (I) with 1,3-dibromopropane (II) by means of NaH in DMF or triethylbenzylammonium chloride NaOH in toluene - water.
参考文献标题:Pyrazoloindazole derivatives and bronchodilating composition
文献作者:Fujimura,Y.; et al.
参考来源:EP 0023633; JP 56015287; US 4409234