NECA
Chemical Name: N5'-Ethyladenosine-5'-uronamide ; Adenosin-5'-oic acid ethylamide
项目整合开发状态: Biological Testing
项目研究机构: Abbott (Originator)
合成路线:The oxidation of 2',3'-isopropylideneadenosine (I) with potassium permanganate gives 2',3'-isopropylideneadenosine-5'-carboxylic acid (II) which with SOCl2 affords 2',3'-isopropylideneadenosine-5'-carbonyl chloride (III),which is treated first with dry liquid ethylamine and then hydrolyzed with aqueous hydrochloric acid.
📌 参考资料/链接：
参考文献标题:Modifications of the 5' position of purine nucleosides.2.Synthesis and some cardiovascular properties of adenosine-5'-(N-substituted)carboxamides
文献作者:Prasad,R.N.; Bariana,D.S.; Fung,A.; Savic,M.; Tietje,K.; Stein,H.H.; Brondyk,H.; Egan,R.S.
参考来源:J Med Chem 1980,23(3),313-319
📄 详细内容
合成路线:The oxidation of 2',3'-isopropylideneadenosine (I) with potassium permanganate gives 2',3'-isopropylideneadenosine-5'-carboxylic acid (II) which with SOCl2 affords 2',3'-isopropylideneadenosine-5'-carbonyl chloride (III),which is treated first with dry liquid ethylamine and then hydrolyzed with aqueous hydrochloric acid.
参考文献标题:
文献作者:Stein,H.H.; Prasad,R.N.
参考来源:US 4029884
合成路线:The oxidation of 2',3'-isopropylideneadenosine (I) with potassium permanganate gives 2',3'-isopropylideneadenosine-5'-carboxylic acid (II) which with SOCl2 affords 2',3'-isopropylideneadenosine-5'-carbonyl chloride (III),which is treated first with dry liquid ethylamine and then hydrolyzed with aqueous hydrochloric acid.
参考文献标题:
文献作者:Stein,H.H.; Prasad,R.N.
参考来源:US 3966917
合成路线:The oxidation of 2',3'-isopropylideneadenosine (I) with potassium permanganate gives 2',3'-isopropylideneadenosine-5'-carboxylic acid (II) which with SOCl2 affords 2',3'-isopropylideneadenosine-5'-carbonyl chloride (III),which is treated first with dry liquid ethylamine and then hydrolyzed with aqueous hydrochloric acid.
参考文献标题:
文献作者:Stein,H.H.; Prasad,R.N.
参考来源:US 3931401
合成路线:The oxidation of 2',3'-isopropylideneadenosine (I) with potassium permanganate gives 2',3'-isopropylideneadenosine-5'-carboxylic acid (II) which with SOCl2 affords 2',3'-isopropylideneadenosine-5'-carbonyl chloride (III),which is treated first with dry liquid ethylamine and then hydrolyzed with aqueous hydrochloric acid.
参考文献标题:
文献作者:Stein,H.H.; Prasad,R.N.
参考来源:US 3914415
合成路线:The oxidation of 2',3'-isopropylideneadenosine (I) with potassium permanganate gives 2',3'-isopropylideneadenosine-5'-carboxylic acid (II) which with SOCl2 affords 2',3'-isopropylideneadenosine-5'-carbonyl chloride (III),which is treated first with dry liquid ethylamine and then hydrolyzed with aqueous hydrochloric acid.
参考文献标题:
文献作者:Stein,H.H.; Prasad,R.N.
参考来源:US 3914414
合成路线:The oxidation of 2',3'-isopropylideneadenosine (I) with potassium permanganate gives 2',3'-isopropylideneadenosine-5'-carboxylic acid (II) which with SOCl2 affords 2',3'-isopropylideneadenosine-5'-carbonyl chloride (III),which is treated first with dry liquid ethylamine and then hydrolyzed with aqueous hydrochloric acid.
参考文献标题:
文献作者:Stein,H.H.; Prasad,R.N.
参考来源:US 3830796