新产品编号:2506397

Chemical Name: N-[2-(2-Benzoxazolyl)ethyl]guanidine hydrochloride
项目整合开发状态: Preclinical
项目研究机构: FAES (Originator)
合成路线:Treatment of beta-alanine (I) with phthalic anhydride (II) in refluxing toluene provides phthalimidopropionic acid (III),which upon cyclocondensation with 2-aminophenol (IV) in hot polyphosphoric acid provides the benzoxazole derivative (V).Hydrazinolysis of phthalimide (V) affords the primary amine (VI),which is finally condensed with pyrazole-1-carboxamidine hydrochloride (VII) in DMF to produce the target guanidine compound.