新产品编号:2501651

Chemical Name: 3-(2-Chlorophenyl)-1-(2,5-dihydroxyphenyl)-2-propen-1-one
项目整合开发状态: Preclinical
项目研究机构: Chungnam National University (Originator), Korea Res. Inst. Biosci. Biotechnol. (Originator)
合成路线:Reaction of 2',5'-dihydroxyacetophenone (I) with dihydropyran (II) and pyridinium p-toluenesulfonate gives the protected bis-tetrahydropyranyl ether (III),which is submitted to Claisen-Schmidt condensation with 2-chlorobenzaldehyde (IV) in the presence of barium hydroxide,yielding the chalcone (V).Finally,the tetrahydropyranyl protecting groups of (V) are removed by acidic hydrolysis with p-toluenesulfonic acid in MeOH.