新产品编号:2500069
Chemical Name: (?-cis-1-Hydroxy-6-methoxy-3,3,14-trimethyl-2-(4-pentenoyloxy)-2,3,7,14-tetrahydro-1H-benzo[b]pyrano[3,2-h]acridin-7-one; 4-Pentenoic acid cis-1-hydroxy-6-methoxy-3,3,14-trimethyl-7-oxo-2,3,7,14-tetrahydro-1H-benzo[b]pyrano[3,2-h]acridin-2-yl ester
项目整合开发状态: Preclinical
项目研究机构: CNRS (Originator), INSERM (Originator), Servier (Originator)
合成路线:Dihydroxylation of the benzo[b]pyrano[3,2-h]acridinone derivative (I) by means of N-methylmorpholine-N-oxide in the presence of OsO4 leads to the cis-diol (II),which upon esterification with 4-pentenoyl chloride in pyridine furnishes a mixture of diester (III) and the title mono-pentenoate ester,which can be separated employing flash chromatography.
📌 参考资料/链接：
参考文献标题:Structure-activity relationships and mechanism of action of antitumor benzo[b]pyrano[3,2-h]acridin-7-one acronycine analogues
文献作者:Mai,H.D.T.; Gaslonde,T.; Michel,S.; Tillequin,F.; Koch,M.; Bongui,J.-B.; Elomri,A.; Seguin,E.; Pfeiffer,B.; Renard,P.; David-Cordonnier,M.-H.; Laine,W.; Bailly,C.; Kraus-Berthier,L.; Leonce,S.; Hickman,J.A.; Pierre,A.
参考来源:J Med Chem 2003,46(14),3072