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新产品编号:2492159

Chemical Name: (E)-N'-(4-Bromophenylmethylene)-1-(4-chlorophenyl)-1H-1,2,3-triazole-4-carbohydrazide
项目整合开发状态: Preclinical
项目研究机构: Universidade Federal do Rio de Janeiro (Originator)
合成路线:The triazolecarboxaldehyde (I) is oxidized by means of MnO2 in the presence of NaCN in MeOH to produce the methyl ester (II).Subsequent reaction of ester (II) with hydrazine hydrate leads to hydrazide (III).This is then condensed with 4-bromobenzaldehyde (IV) to furnish the target acylhydrazone derivative.
📌 参考资料/链接:
参考文献标题:Antiplatelet properties of novel N-substituted-phenyl-1,2,3-triazole-4-acylhydrazone derivatives
文献作者:Cunha,A.C..; Figueiredo,J.M.; Tributino,J.L.M.; Miranda,A.L.P.; Castro,H.C.; Zingali,R.B.; Fraga,C.A.M.; de Souza,M.C.B.V.; Ferreira,V.F.; Barreiro,E.J.
参考来源:Bioorg Med Chem 2003,11(9),2051