新产品编号:2488995

Chemical Name: [7,12-Bis[1-(methoxypolyethyleneglycol-350)ethyl]-3,8,13,17-tetramethyl-21H,23H-porphyrin-2,18-dipropionato](trans-cyclohexane-1,2-diamine)platinum(II)
项目整合开发状态: Preclinical
项目研究机构: Ewha Womans University (Originator), Korea Inst. Sci. Technol. (Originator), Yonsei University (Originator)
合成路线:Hematoporphyrin IX (I) is treated with an acetic acid solution of HBr to afford dibromide (II).Condensation of (II) with polyethyleneglycol 350 monomethyl ether,followed by alkaline hydrolysis of the ester groups generated during the reaction furnishes the polyethyleneglycol-conjugated porphyrin derivative (III).Then,complexation of the potassium salt of porphyrin diacid (III) with cis-[(trans-1,2-diaminocyclohexane)platinum(II)] sulfate (IV) by means of KOH in H2O gives rise to the title hematoporphyrin-platinum conjugate.