新产品编号:2484249
Chemical Name: 8-Chloro-2-phenylamino[1,2,4]triazolo[1,5-b][1,4,2]benzodithiazine-7-carbonitrile 5,5-dioxide
项目整合开发状态: Biological Testing
项目研究机构: Medical University of Gdansk (Originator), Uniwersytet im Adama Mickiewicza (Originator)
合成路线:Reaction of the 3-(methylsulfanyl)benzodithiazine (I) with 4-phenylsemicarbazide (II) in boiling MeOH affords adduct (III).Subsequent cyclization of (III) with concomitant amide dehydration in boiling POCl3 furnishes the title tricyclic compound.
📌 参考资料/链接:
参考文献标题:Synthesis and anticancer activity of 2-amino-8-chloro-5,5-dioxo[1,2,4]triazolo[2,3-b][1,4,2]benzodithiazine derivatives
文献作者:Pomarnacka,E.; Gdaniec,M.
参考来源:Bioorg Med Chem 2003,11(7),1259