新产品编号:2476339
Chemical Name: N-(5-Phenyloxazol-2-yl)isoquinolin-6-amine
项目整合开发状态: Biological Testing
项目研究机构: Bristol-Myers Squibb (Originator)
合成路线:Treatment of 6-aminoisoquinoline (I) with 1,1'-thiocarbonyldi-2(1H)-pyridone (II) provides the isothiocyanate (III).Subsequent condensation of (III) with 2-azidoacetophenone (IV) in the presence of triphenylphosphine affords the title oxazole derivative.
📌 参考资料/链接：
参考文献标题:Identification of novel and potent isoquinoline aminooxazole-based IMPDH inhibitors
文献作者:Chen,P.; Norris,D.; Haslow,K.D.; Dhar,T.G.M.; Pitts,W.J.; Watterson,S.H.; Cheney,D.L.; Bassolino,D.A.; Fleener,C.A.; Rouleau,K.A.; Hollenbaugh,D.L.; Townsend,R.M.; Barrish,J.C.; Iwanowicz,E.J.
参考来源:Bioorg Med Chem Lett 2003,13(7),1345