新产品编号:2473175
Chemical Name: 2-(1-Benzothien-3-yl)-6-methoxy-5-(5-oxazolyl)-1H-indole-3-carbaldehyde
项目整合开发状态: Biological Testing
项目研究机构: Bristol-Myers Squibb (Originator)
合成路线:Condensation of iodoaniline (I) with ethyl 2-(methylsulfanyl)acetate (II) in the presence of sulfuryl chloride gives rise to the oxindole derivative (III).Desulfuration of (III) by means of Raney-nickel then affords (IV).The Vilsmeier-Haack reaction of oxindole (IV) with POBr3 and DMF leads to the bromo aldehyde (V).This is finally subjected to Suzuki coupling with 3-benzothienylboronic acid (VI) to furnish the title compound.
📌 参考资料/链接：
参考文献标题:Novel indole-based inhibitors of IMPDH: Introduction of hydrogen bond acceptors at indole C-3
文献作者:Watterson,S.H.; Dhar,T.G.M.; Ballentine,S.K.; Shen,Z.; Barrish,J.C.; Cheney,D.; Fleener,C.A.; Rouleau,K.A.; Townsend,C.; Hollenbaugh,D.L.; Iwanowicz,E.J.
参考来源:Bioorg Med Chem Lett 2003,13(7),1273