新产品编号:2466847
Chemical Name: N-(6-Amino-3-methyl-2,4-dioxo-1-phenyl-1,2,3,4-tetrahydropyrimidin-5-yl)-3-(3,5-di-tert-butyl-4-hydroxyphenyl)-2-propenamide
项目整合开发状态: Preclinical
项目研究机构: Japan Energy (Originator)
合成路线:Nitrosation of pyrimidinedione (I) with NaNO2/HCl affords (II),which is further reduced to the diaminopyrimidine (III) by catalytic hydrogenation over Pd/C.Subsequent coupling of (III) with 2,6-di-tert-butyl-4-hydroxycinnamic acid (IV) employing DPP-Cl furnishes the title amide
📌 参考资料/链接：
参考文献标题:Inhibitory activities of novel pyrimidine derivatives on the contact hypersensitivity reaction
文献作者:Isobe,Y.; Tobe,M.; Inoue,Y.; Goto,Y.; Obara,F.; Isobe,M.; Hayashi,H.
参考来源:Chem Pharm Bull 2003,51(3),309