新产品编号:2463683
Chemical Name: N-[3-(Benzyloxy)phenyl]-N'-hydroxyoctanediamide; 7-[N-[3-(Benzyloxy)phenyl]carbamoyl]heptanohydroxamic acid
项目整合开发状态: Biological Testing
项目研究机构: Aton Pharma (Originator)
合成路线:3-(Benzyloxy)aniline (I) is acylated by suberic acid mono-methyl ester (II) either employing EDC as the coupling reagent or via activation with oxalyl chloride to produce the suberoyl anilide (III).Further displacement of the methyl ester group of (III) with hydroxylamine in the presence of NaOMe leads to the target hydroxamic acid
📌 参考资料/链接：
参考文献标题:SAHA derived inhibitors of histone deacetylase (HDAC)
文献作者:Belvedere,S.; Zhou,W.; Witter,D.; Yan,J.; Chen,W.; Secrist,J.P.; Richon,V.; Miller,T.
参考来源:225th ACS Natl Meet (March 23 2003,New Orleans) 2003,Abst MEDI 102