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新产品编号:2438371

Chemical Name: 2-Acetoxybenzoic acid 4-cyano-5-oxido-1,2,5-oxadiazol-3-ylmethyl ester
项目整合开发状态: Preclinical
项目研究机构: Universit?degli Studi di Parma (Originator), Universit?degli Studi di Torino (Originator), University of Edinburgh (Originator)
合成路线:Reaction of acetylsalicylic acid (I) with 4-bromomethyl-3-carbamoylfuroxan (II) provides the furoxanylmethyl ester (III).Subsequent trifluoroacetic anhydride-promoted dehydration of amide (III) yields the corresponding cyano derivative.
📌 参考资料/链接:
参考文献标题:Antiinflammatory,gastrosparing,and antiplatelet properties of new NO-donor esters of aspirin
文献作者:Cena,C.; Lolli,M.L.; Lazzarato,L.; Guaita,E.; Morini,G.; Coruzzi,G.; McElroy,S.P.; Megson,I.L.; Fruttero,R.; Gasco,A.
参考来源:J Med Chem 2003,46(5),747