新产品编号:2436789
Chemical Name: 2-[2,4-Bis(4-methoxybenzoyl)-1H-pyrrol-1-yl]acetic acid
项目整合开发状态: Preclinical
项目研究机构: Aristotle University of Thessaloniki (Originator)
合成路线:Friedel-Crafts acylation of 3-(p-methoxybenzoyl)pyrrole (I) with p-methoxybenzoyl chloride (II) gives rise to diketone (III).Subsequent alkylation of pyrrole (III) with ethyl bromoacetate (IV) in the presence of NaH and tris[(2-methoxyethoxy)ethyl]amine (TDA) furnishes the pyrrolylacetate (V).Finally,saponification of the ethyl ester group of (V) affords the target carboxylic acid.
📌 参考资料/链接：
参考文献标题:Substituted pyrrol-1-ylacetic acids that combine aldose reductase enzyme inhibitory activity and ability to prevent the nonenzymatic irreversible modification of proteins from monosaccharides
文献作者:Nicolaou,I.; Demopoulos,V.J.
参考来源:J Med Chem 2003,46(3),417