PH-027
Chemical Name: 3-[3-Fluoro-4-(4-morpholinyl)phenyl]-5(R)-(1H-1,2,3-triazol-1-ylmethyl)oxazolidin-2-one
项目整合开发状态: Preclinical
项目研究机构: Kuwait University (Originator)
合成路线:The known oxazolidine methansulfonate (I) is reacted with NaN3 in hot DMF to produce azide (II).Then,condensation of azide (II) with acetylene (III) at 90 C in a pressure vessel gives rise to the target triazole derivative.
📌 参考资料/链接：
参考文献标题:Synthesis and antibacterial activity of 5-substituted oxazolidinones
文献作者:Phillips,O.A.; Udo,E.E.; Ali,A.A.M.; Al-Hassawi,N.
参考来源:Bioorg Med Chem 2003,11(1),35