新产品编号:2433625

Chemical Name: 2-(2-Methoxyphenyl)-5-(4-methylphenylamino)-3-phenyl-1,2,4-thiadiazol-2-ium bromide
项目整合开发状态: Preclinical
项目研究机构: Johnson & Johnson (Originator)
合成路线:Condensation between ortho-anisidine (I) and benzonitrile (II) in the presence of NaNH2 furnishes N-(2-methoxyphenyl)benzamidine (III).Subsequent condensation of (III) with p-tolyl isothiocyanate (IV) produces the imidoyl thiourea (V).This is then oxidized by bromine in CHCl3 to form the target thiadiazolium salt.