MJ 10459-2
Chemical Name: 5-(3,4-Dichlorophenyl)-4,5-dihydro-1H-imidazol-2-amine hydrobromide
项目整合开发状态: Biological Testing
项目研究机构:
合成路线:It is prepared through the following sequence: The Strecker reaction of 3,4-dichlorobenzaldehyde (I) with sodium cyanide and NH4Cl affords alpha-amino-3,4-dichlorophenylacetonitrile (II) (HCl salt,m.p.184-5 C),which is reduced with LiAlH4 to 2-amino-1-(3',4'-dichlorophenyl)ethylamine (III) (di HCl salt,m.p.283-5 C).Finally compound (III) is cyclized with BrCN in benzene.
📌 参考资料/链接：
参考文献标题:M J 10459 - 2
文献作者:Casta馿r,J.; Blancafort,P.
参考来源:Drugs Fut 1976,1(5),250
📄 详细内容
合成路线:It is prepared through the following sequence: The Strecker reaction of 3,4-dichlorobenzaldehyde (I) with sodium cyanide and NH4Cl affords alpha-amino-3,4-dichlorophenylacetonitrile (II) (HCl salt,m.p.184-5 C),which is reduced with LiAlH4 to 2-amino-1-(3',4'-dichlorophenyl)ethylamine (III) (di HCl salt,m.p.283-5 C).Finally compound (III) is cyclized with BrCN in benzene.
参考文献标题:9-Cis retinoic acid enhances the effectiveness of PPARgamma-specific agonists in non-small cell lung cancer (NSCLC) cell lines
文献作者:Mathier,W.L.; et al.
参考来源:J Med Chem 1973,16901