[18F]-FEDAA-1106

Chemical Name: N-[2-(2-[18-F]-Fluoroethoxy)-5-methoxybenzyl]-N-(5-fluoro-2-phenoxyphenyl)acetamide
项目整合开发状态: Preclinical
项目研究机构: Japan Science and Technology (Originator), National Institute Radiological Sciences (Originator)
合成路线:Reaction of diiodomethane (I) with [18F]fluoride at 100 C leads to the radiolabeled fluoromethyl iodide (II).The known peripheral benzodiazepine receptor ligand (III) is then alkylated with iodide (II) in the presence of NaH in DMF to furnish the title compound.

合成路线:Reaction of 2-bromoethyl triflate (I) with [18F]fluoride in boiling o-dichlorobenzene leads to the radiolabeled 1-bromo-2-fluoroethane (II).The known peripheral benzodiazepine receptor ligand (III) is then alkylated with bromide (II) in the presence of NaH in hot DMF to furnish the title compound.