YM-215389
Chemical Name: 5-Bromo-N-(4-chloro-5-isopropyl-3-methylthiazol-2(3H)-ylidene)-2-hydroxybenzenesulfonamide
项目整合开发状态: Biological Testing
项目研究机构: Yamanouchi (Originator)
合成路线:Acylation of 2-amino-4-chloro-5-isopropylthiazole (I) with 5-bromo-2-methoxybenzenesulfonyl chloride (II) yields sulfonamide (III).Methylation of (III) with ICH3/NaH takes place at the thiazole N,producing (IV).Finally,methyl ether cleavage in (IV) by means of BBr3 in cold CHCl3 affords the title compound.
📌 参考资料/链接：
参考文献标题:Synthesis and structure-activity relationships of novel non-nucleoside HIV-1 reverse transcriptase inhibitors
文献作者:Yamamoto,O.; Fujii,M.; Ohgami,T.; et al.
参考来源:42nd Intersci Conf Antimicrob Agents Chemother (Sept 27 2002,San Diego) 2002,Abst F-1700