SB-214111
Chemical Name: 4-Bromo-N-[4-methoxy-3-(4-methylpiperazin-1-yl)phenyl]benzenesulfonamide
项目整合开发状态: Preclinical
项目研究机构: GlaxoSmithKline (Originator)
合成路线:Treatment of ethyl 2-chloro-4-trifluoromethylpyrimidine-5-carboxylate (I) with hydrazine in THF gives the hydrazinopyrimidine (II).This is subsequently condensed with citraconic anhydride (III) in boiling chloroform to produce the N-(dioxopyrrolidinyl)aminopyrimidine (IV).Finally,N-alkylation of (IV) by means of iodomethane and NaH furnishes the title compound.
📌 参考资料/链接：
参考文献标题:Pyrimidine carboxylates and related cpds.and methods for treating inflammatory conditions
文献作者:Suto,M.J.; Gayo,L.M.; Palanki,M.S.S.; Ransone-Fong,L.J.(Signal Pharmaceuticals,Inc.)
参考来源:JP 1999512390; US 5852028; WO 9709325
📄 详细内容
合成路线:Treatment of ethyl 2-chloro-4-trifluoromethylpyrimidine-5-carboxylate (I) with hydrazine in THF gives the hydrazinopyrimidine (II).This is subsequently condensed with citraconic anhydride (III) in boiling chloroform to produce the N-(dioxopyrrolidinyl)aminopyrimidine (IV).Finally,N-alkylation of (IV) by means of iodomethane and NaH furnishes the title compound.
参考文献标题:Pyrimidine carboxylates and related cpds.and methods for treating inflammatory conditions
文献作者:Suto,M.J.; Gayo,L.M.; Ransone-Fong,L.J.; Palanki,M.S.S.(Signal Pharmaceuticals,Inc.)
参考来源:WO 9838171