Chackol

Chemical Name: Benzoic acid (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-diacetoxy-9-[3(S)-benzamido-2(R)-[3-[N-[4-oxo-4-(D-glucopyranosyloxy)butyl]carbamoyl]propionyloxy]-3-phenylpropionyloxy]-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-d
项目整合开发状态: Biological Testing
项目研究机构: Organomed (Originator)
合成路线:Esterification of glucose diacetonide (I) with N-Boc-gamma-aminobutyric acid (II) in the presence of DCC and DMAP provides the protected glucose-3-ester (III).Hydrolysis of (III) with trifluoroacetic acid in CH2Cl2 leads to the 3-GABA-glucose (IV).

合成路线:Condensation of paclitaxel (V) with succinic anhydride (VI) affords the hemisuccinate ester (VII).This is subsequently coupled with amino ester (IV) in the presence of DCC to furnish the title compound.