BDPX

Chemical Name: 7-Benzyl-1,3-dimethyl-8-(1-piperazinyl)-2,3,6,7-tetrahydro-1H-purine-2,6-dione; 7-Benzyl-1,3-dimethyl-8-(1-piperazinyl)xanthine
项目整合开发状态: Preclinical
项目研究机构: Novo Nordisk (Originator)
合成路线:Alkylation of 8-chloro-1,3-dimethylxanthine (I) with benzyl bromide and K2CO3 affords the 7-benzyl purine (II).This is then condensed with N-Boc-piperazine (III) in EtOH upon heating at 120 C in a sealed vessel to provide the 8-piperazinyl derivative (IV).Finally,deprotection of (IV) employing trifluoroacetic acid leads to the title compound