新产品编号:2359271
Chemical Name: 1-(3-Bromophenyl)propan-1-one thiosemicarbazone
项目整合开发状态: Biological Testing
项目研究机构: Pfizer (Originator), University of California, Oakland (Originator)
合成路线:The title thio semicarbazone is prepared by condensation of 3-bromopropiophenone (I) with thio semicarbazide (II) in MeOH in the presence of a catalytic amount of HOAc.(1,2)
📌 参考资料/链接：
参考文献标题:Thio semicarbazone and semicarbazone inhibitors of cysteine proteases and methods of their use
文献作者:Du,X.; Cohen,F.E.; McKerrow,J.H.; Guo,C.(University of California,Oakland)
参考来源:US 2004014801
📄 详细内容
合成路线:The title thio semicarbazone is prepared by condensation of 3-bromopropiophenone (I) with thio semicarbazide (II) in MeOH in the presence of a catalytic amount of HOAc.(1,2)
参考文献标题:Synthesis and structure-activity relationship study of potent trypanocidal thio semicarbazone inhibitors of the trypanosomal cysteine protease cruzain
文献作者:Du,X.; et al.
参考来源:J Med Chem 2002,45(13),2695