新产品编号:2356107

Chemical Name: 5-(4-Fluorophenyl)-2-[2-(methylsulfinyl)benzylsulfanyl]-4-(4-pyridyl)pyrimidine
项目整合开发状态: Biological Testing
项目研究机构: Universit鋞 T黚ingen (Originator)
合成路线:Condensation of 2-(4-fluorophenyl)-1-(4-pyridyl)ethanone (I) with dimethylformamide-dimethylacetal gives the enamino ketone (II).This is cyclized with thiourea (III) in the presence of NaOEt to produce the pyrimidine-2-thione (IV).Finally,S-alkylation of (IV) with 2-(methylsulfinyl)benzyl chloride (V) yields the target compound.