新产品编号:2352943
Chemical Name: (?-3-[2-Oxo-3-(3-oxopiperidin-2-yl)propyl]quinazolin-4(3H)-one
项目整合开发状态: Preclinical
项目研究机构: Nagasaki University (Originator), Okayama University (Originator), Tohoku University (Originator)
合成路线:Febrifugine (I) is protected as the tert-butyl carbamate (II) by treatment with Boc2O.Oxidation of the secondary alcohol group of (II) employing Dess-Martin periodinane gives rise to ketone (III).The N-Boc group of (III) is finally cleaved under acidic conditions to yield the title compound.
📌 参考资料/链接：
参考文献标题:Potent antimalarial febrifugine analogues against the Plasmodium malaria parasite
文献作者:Kikuchi,H.; Tasaka,H.; Hirai,S.; Takaya,Y.; Iwabuchi,Y.; Ooi,H.e.; Hatakeyama,S.; Kim,H.S.; Wataya,Y.; Oshima,Y.
参考来源:J Med Chem 2002,45(12),2563