新产品编号:2333959
Chemical Name: 5-(2,3-Dihydroxyphenyl)-3-hydroxy-4-phenylfuran-2(5H)-one
项目整合开发状态: Biological Testing
项目研究机构: Univ. Blaise Pascal-Clermont-Ferrand II (Originator), Universit?d'Auvergne-Clermont-Ferrand (Originator)
合成路线:Methylation of phenylpyruvic acid (I) with iodomethane and DBU affords the methyl phenylpyruvate (II).Subsequent condensation of keto ester (II) with 2,3-dihydroxybenzaldehyde (III) in the presence of DBU,followed by acidic quenching provides the target furanone derivative
📌 参考资料/链接：
参考文献标题:Novel 4,5-diaryl-3-hydroxy-2(5H)-furanones as anti-oxidants and anti-inflammatory agents
文献作者:Weber,V.; Coudert,P.; Rubat,C.; Duroux,E.; Vallee-Goyet,D.; Gardette,D.; Bria,M.; Albuisson,E.; Leal,F.; Gramain,J.C.; Couquelet,J.; Madesclaire,M.
参考来源:Bioorg Med Chem 2002,10(6),1647