新产品编号:2332377

Chemical Name: 1,10-Diazabicyclo[8.3.1]tetradeca-5,12-diene-3,7-diyne-11,14-dione
项目整合开发状态: Biological Testing
项目研究机构: Academia Sinica (Originator), University of Alberta (Originator)
合成路线:Alkylation of uracil (I) with propargyl bromide (II) in the presence of DBU affords the N1-alkylated product (III).Palladium-catalyzed coupling of the terminal alkyne (III) with cis-1,2-dichloroethene (IV) furnishes the chlorovinyl adduct (V).Subsequent alkylation at the N3-position of (V) with propargyl bromide (II) and DBU leads to the open-chain enediyne (VI).This is finally cyclized to the target bicyclic compound in the presence of Pd(PPh3)4,CuI and butylamine.