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新产品编号:2324467

Chemical Name: Diammine[7,12-bis[1-(methoxypolyethyleneglycol-750)ethyl]-3,8,13,17-tetramethyl-21H,23H-porphyrin-2,18-dipropionato]platinum
项目整合开发状态: Biological Testing
项目研究机构: Universit鋞 Regensburg (Originator)
合成路线:Protoporphyrin dimethyl ester (I) is treated with HBr in HOAc to produce dibromide (II).Displacement of the bromide groups of (II) by poly(ethyleneglycol)-750-mono-methyl ether,followed by alkaline hydrolysis of the concomitantly transesterified ester groups,furnishes the porphyrin di-ether (III).This is finally complexed with diammine(diaqua)platinum(II) hydroxide to yield the title compound.
📌 参考资料/链接:
参考文献标题:Hematoporphyrin-derived soluble porphyrin-platinum conjugates with combined cytotoxic and phototoxic antitumor activity
文献作者:Lottner,C.; Bart,K.C.; Bernhardt,G.; Brunner,H.
参考来源:J Med Chem 2002,45(10),2064