新产品编号:2322885
Chemical Name: 5-(1-Azidovinyl)-1-[4-hydroxy-3-(hydroxymethyl)butyl]pyrimidine-2,4(1H,3H)-dione; 5-(1-Azidovinyl)-1-[4-hydroxy-3-(hydroxymethyl)butyl]uracil
项目整合开发状态: Biological Testing
项目研究机构: University of Alberta (Originator)
合成路线:The reaction of the 5-vinyluracil derivative (I) with NBS and NaN3 in dimethoxyethane gives the 1-azido-2-bromoethyluracil derivative (II),which is treated with potassium tert-butoxide in THF to yield the 1-azidovinyluracil compound (III).Finally,this compound is debenzoylated with ammonia in methanol to afford the target dihydroxylated uracil derivative.
📌 参考资料/链接：
参考文献标题:Design and synthesis of novel 5-substituted acyclic pyrimidine nucleosides as potent and selective inhibitors of hepatitis B virus
文献作者:Kumar,R.; Nath,M.; Tyrrell,D.L.
参考来源:J Med Chem 2002,45(10),2032