PPK-12

Chemical Name: 4-(2-Ethoxy-6-pentadecylphenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid ethyl isopropyl diester
项目整合开发状态: Biological Testing
项目研究机构: University of Calgary (Originator), Vittal Mallya Scientific Res Foundation (Originator)
合成路线:Treatment of anacardic acid (I) with diethyl sulfate produces the dialkylated derivative (II).Ester group reduction in (II) employing LiAlH4 then yields the benzylic alcohol (III),which is further oxidized to aldehyde (IV) with pyridinium chlorochromate.Condensation of aldehyde (IV) with ethyl acetoacetate (V) in the presence of piperidine and AcOH gives the benzylidene acetoacetate (VI).This is finally condensed with enamino ester (VII) under modified Hantzsh conditions to furnish the target dihydropyridine compound.