新产品编号:2273843

Chemical Name: 5(R)-(Methoxymethyl)-3-(1H-pyrrol-1-yl)oxazolidin-2-one
项目整合开发状态: Biological Testing
项目研究机构: Universit?degli Studi "La Sapienza" (Originator), Universit?degli Studi di Salerno (Originator), Universit?degli Studi di Siena (Originator)
合成路线:Condensation of benzyl carbazate (I) with 2,5-dimethoxytetrahydrofuran (II) affords the N-benzyloxycarbonyl aminopyrrole (III).The lithiated derivative of (III) is condensed with (R)-glycidyl butyrate (IV) to furnish the chiral oxazolidinone (V).Alcohol (V) is converted to the corresponding mesylate (VI) with methanesulfonyl chloride and triethylamine.Finally,nucleophilic displacement of mesylate (VI) with sodium methoxide affords the target methyl ether.