新产品编号:2272261
Chemical Name: 5-[(1aS,8S,8aR,8bS)-6-Amino-8-(carbamoyloxymethyl)-8a-methoxy-5-methyl-4,7-dioxo-1,1a,2,4,7,8,8a,8b-octahydroazirino[2',3':3,4]pyrrolo[1,2-a]indol-1-yl]-5-oxopentanoic acid9-fluoro-11beta-hydroxy-16alpha,17-(isopropylidenedioxy)-3,20-dioxopregna-1,4-die
项目整合开发状态: Preclinical
项目研究机构: Medical University of South Carolina (Originator)
合成路线:The reaction of triamcinolone (I) with acetone and HCl gives the corresponding acetonide (II),which is condensed with glutaric anhydride (III) in pyridine to yield the glutaric monoester (IV).Finally,this compound is condensed with mitomycin C (V) by means of CDI in THF to afford the target conjugate.
📌 参考资料/链接：
参考文献标题:Synthesis,pharmacokinetics,efficacy,and rat retinal toxicity of a novel mitomycin C-triamcinolone acetonide conjugate
文献作者:Macky,T.A.; Oelkers,C.; Rix,U.; Heredia,M.L.; K黱zel,E.; Winberly,M.; Rohr,J.; Crosson,C.E.; Rohrer,B.
参考来源:J Med Chem 2002,45(5),1122