C-6458
Chemical Name: 4-Amino-5-(1H-indol-1-ylmethyl)-3,4-dihydro-2H-1,2,4-triazole-3-thione
项目整合开发状态: Preclinical
项目研究机构: Aristotle University of Thessaloniki (Originator), Onassis Cardiac Surgery Center (Originator), University of Athens (Originator)
合成路线:Condensation of indolyl acetohydrazide (I) with carbon disulfide in the presence of KOH afforded the potassium dithiocarbazate (II),which was further cyclized to the target aminotriazole thione upon refluxing with aqueous hydrazine.
📌 参考资料/链接：
参考文献标题:Antioxidant activity of novel indole derivatives and protection of the myocardial damage in rabbits
文献作者:Andreadou,I.; Tasouli,A.; Bofilis,E.; Chrysselis,M.C.; Rekka,E.A.; Tsantili-Kakoulidou,A.; Iliodromitis,E.; Siatra,T.; Kremastinos,D.T.
参考来源:Chem Pharm Bull 2002,50(2),165