新产品编号:2259605

Chemical Name: Quinuclidin-3-one O-2-butynyloxime
项目整合开发状态: Preclinical
项目研究机构: DSO National Laboratories (Originator), National University of Singapore (Originator)
合成路线:N-(2-Butynyloxy)phthalimide (III) was obtained by the Mitsunobu coupling between 2-butyn-1-ol (II) and N-hydroxyphthalimide (I).Subsequent hydrazinolysis of (III) gave the O-alkynyl hydroxylamine (IV).This was finally condensed with quinuclidin-3-one (V) in methanol to furnish the corresponding oxime.