新产品编号:2258023

Chemical Name: 2-(6-Methoxy-6-pentyl-1,2-dioxan-3-yl)acetic acid methyl ester
项目整合开发状态: Preclinical
项目研究机构: Osaka University (Originator)
合成路线:Treatment of gamma-butyrolactone (I) with N,O-dimethylhydroxylamine in the presence of dimethylaluminium chloride afforded the corresponding Weinreb amide (II),which was converted to the keto-alcohol (III) by addition of pentylmagnesium bromide.Swern oxidation of alcohol (III),followed by Wittig reaction of the resultant aldehyde (IV) with (methoxycarbonylmethylene)triphenylphosphorane (V),provided the unsaturated keto ester (VI).Subsequent scandium triflate-mediated peroxyhemiacetalyzation of ketone (VI) gave rise to (VII).Then,intramolecular Michael addition of the hydroperoxy ester (VII) in the presence of diethylamine generated the target cyclic peroxide.