新产品编号:2254859

Chemical Name: N-(3,4-Dichlorophenyl)-2-(3,5-dimethylphenoxy)-N-(4-piperidinyl)acetamide
项目整合开发状态: Preclinical
项目研究机构: UCB Pharma (Originator)
合成路线:The reductocondensation of N-Boc-piperidin-4-one (I) with 3,4-dichloroaniline (II) by means of NaHB(OAc)3 in dichloroethane gives the secondary amine (III),which is acylated with chloroacetyl chloride (IV) by means of K2CO3 in dichloromethane to yield the chloroacetamide (V).The reaction of (V) with 3,5-dimethylphenol (VI) by means of Cs2CO3 in acetonitrile affords the aryl ether (VII),which is finally Boc deprotected with TFA in dichloromethane to provide the title trisubstituted acetamide.