新产品编号:2251695

Chemical Name: 2,6-Di-tert-butyl-4-[3-[4-[2-hydroxy-3-(isoquinolin-5-yloxy)propylamino]phenoxy]propyl]phenol
项目整合开发状态: Biological Testing
项目研究机构: CNRS (Originator), Duke University (Originator), Universit?Joseph Fourier (Originator)
合成路线:Reduction of 3-(3,5-di-t-butyl-4-hydroxyphenyl)propionic acid (I) with LiAlH4 afforded alcohol (II),which was further brominated to (III) using PBr3.Alkylation of p-nitrophenol (IV) by the alkyl bromide (III) gave ether (V).Then,reduction of the nitro group of (V) to the aniline (VI) was accomplished by means of hydrazine in the presence of Raney nickel.

合成路线:Alkylation of 5-hydroxyisoquinoline (VII) with epibromohydrin (VIII) produced the glycidyl ether (IX).Subsequent epoxide ring opening in (IX) with aniline (VI) furnished the target (isoquinolyloxy)propanolamine.