新产品编号:2106151

Chemical Name: 2-[3-[2,5-Bis-O-[tert-butyl(dimethyl)silyl]-beta-D-ribofuranosyl]thymin-3-yl]acetic acid
项目整合开发状态: Biological Testing
项目研究机构: CSIC (Originator), Rega Institute for Medical Research (Originator)
合成路线:Alkylation of the previously reported 2',5'-bis-silylated nucleoside (I) with benzyl bromoacetate (II) in the presence of K2CO3 in acetone provided the N-3-substituted derivative (III).The benzyl ester group was then removed by catalytic hydrogenation over Pd/C to furnish the target carboxylic acid.