新产品编号:2102987
Chemical Name: (-)-1-(10,11-Dihydro-5H-dibenzo[b,f]azepin-5-yl)-3-(isopropylamino)propan-2(S)-ol hydrochloride
项目整合开发状态: Preclinical
项目研究机构: Scripps Research Institute (Originator), Technion - Israel Institute Technol. (Originator), Tel Aviv University (Originator)
合成路线:The reaction of dibenzazepine (I) with the chiral epichlorohydrin (II) by means of NaNH2 in refluxing benzene gives the adduct (III),which is finally treated with isopropylamine (IV) to yield the target isopropanol derivative.
📌 参考资料/链接:
参考文献标题:A new class of antiarrhythmic-defibrillatory agents
文献作者:Levy,O.; Erez,M.; Varon,D.; Keinan,E.
参考来源:Bioorg Med Chem Lett 2001,11(22),2921