FR-252384

Chemical Name: 9-Methyl-2-(3-pyridyl)-3,4,5,6-tetrahydrobenzo[3,4]cyclohepta[1,2-d]imidazole
项目整合开发状态: Preclinical
项目研究机构: Fujisawa (Originator)
合成路线:Nitrosation of the benzocycloheptanone (I) with isoamyl nitrite furnishes the keto oxime (II).Subsequent ring closure of (II) with pyridine-3-carboxaldehyde (III) and ammonium acetate produces the N-hydroxy imidazole derivative (IV).Then,reduction of the N-hydroxy group of (IV) is performed by treatment PCl3 in DMF