新产品编号:2076093

Chemical Name: 2-(4-Isobutylphenyl)propionic acid 3-[5-oxido-4-(phenylsulfonyl)-1,2,5-oxadiazol-3-yloxy]propyl ester
项目整合开发状态: Preclinical
项目研究机构: Ist. di Ricerche Farmacol. Mario Negri (Originator), Universit?degli Studi di Parma (Originator), Universit?degli Studi di Torino (Originator)
合成路线:The furazanyloxypropanol derivative (III) was obtained by condensation of 3,4-bis(benzenesulfonyl)furoxan (I) with 1,3-propanediol (II) in the presence of NaOH.Subsequent acylation of alcohol (III) with ibuprofen acid chloride (IV) provided the corresponding ibuprofen ester.