新产品编号:2074511

Chemical Name: N-[6-[4-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)butyramido]hexyl]carbamic acid 9-fluoro-11,17-dihydroxy-16alpha-methyl-3,20-dioxopregna-1,4-dien-21-yl ester
项目整合开发状态: Biological Testing
项目研究机构: Universit鋞 Bern (Originator)
合成路线:Esterification of the primary hydroxyl group of dexamethasone (I) by treatment with 4-nitrophenyl chloroformate (II) in the presence of N-methylmorpholine afforded the nitrophenyl carbonate (III).Condensation of the active ester (III) with mono-N-Boc-1,6-diaminohexane (IV) produced carbamate (V).After acidic deprotection of the Boc group,the resultant amine (VI) was acylated with succinimidyl 4-maleimidobutyrate (VII),yielding the title amide.