Tiodonium chloride, DL-164
Chemical Name: (4-Chlorophenyl)(2-thienyl)iodonium chloride
项目整合开发状态: Biological Testing
项目研究机构:
合成路线:The oxidation of p-chloroiodobenzene (I) with peracetic acid (II) in acetic acid affords 4-chloroiodosobenzene diacetate (III),which is then condensed with thiophene (IV) by means of acetic anhydride and trifluoroacetic acid yielding (p-chlorophenyl)-2-thienyliodonium trifluoroacetate (V).Finally this salt is treated with HCl in aqueous formic acid.(1-4)
📌 参考资料/链接：
参考文献标题:Tiodonium chloride
文献作者:Casta馿r,J.; Blancafort,P.
参考来源:Drugs Fut 1977,7(6),407
📄 详细内容
合成路线:The oxidation of p-chloroiodobenzene (I) with peracetic acid (II) in acetic acid affords 4-chloroiodosobenzene diacetate (III),which is then condensed with thiophene (IV) by means of acetic anhydride and trifluoroacetic acid yielding (p-chlorophenyl)-2-thienyliodonium trifluoroacetate (V).Finally this salt is treated with HCl in aqueous formic acid.(1-4)
参考文献标题:
文献作者:Moyle,C.L.(Dow Chem.Co.)
参考来源:FR 2153532
合成路线:The oxidation of p-chloroiodobenzene (I) with peracetic acid (II) in acetic acid affords 4-chloroiodosobenzene diacetate (III),which is then condensed with thiophene (IV) by means of acetic anhydride and trifluoroacetic acid yielding (p-chlorophenyl)-2-thienyliodonium trifluoroacetate (V).Finally this salt is treated with HCl in aqueous formic acid.(1-4)
参考文献标题:
文献作者:Moyle,C.L.(Dow Chem.Co.)
参考来源:US 3763187
合成路线:The oxidation of p-chloroiodobenzene (I) with peracetic acid (II) in acetic acid affords 4-chloroiodosobenzene diacetate (III),which is then condensed with thiophene (IV) by means of acetic anhydride and trifluoroacetic acid yielding (p-chlorophenyl)-2-thienyliodonium trifluoroacetate (V).Finally this salt is treated with HCl in aqueous formic acid.(1-4)
参考文献标题:
文献作者:Moyle,C.L.(Dow Chem.Co.)
参考来源:US 3885036
合成路线:The oxidation of p-chloroiodobenzene (I) with peracetic acid (II) in acetic acid affords 4-chloroiodosobenzene diacetate (III),which is then condensed with thiophene (IV) by means of acetic anhydride and trifluoroacetic acid yielding (p-chlorophenyl)-2-thienyliodonium trifluoroacetate (V).Finally this salt is treated with HCl in aqueous formic acid.(1-4)
参考文献标题:
文献作者:Moyle,C.L.(Dow Chem.Co.)
参考来源:DE 2145733; GB 1351531